Sarah Wayne Callies has been cast in USA Network's new alien drama pilot "Colony" from former "Lost" co-showrunner Carlton Cuse, Entertainment Weekly reported.

The 37-year-old actress, who played Lori, Rick Grimes (Andrew Lincoln) wife on AMC's "The Walking Dead," is set to play the female lead on the small screen project opposite "Lost" alum Josh Hollaway.

Callies will be playing Katie Bowman, a mother of three, who faces daily struggles to keep her family safe and intact in Los Angeles after a mysterious alien invasion. Katie is the wife of Will (Holloway), a former FBI agent who is forced to collaborate with the alien government in order to bring down the growing resistance movement inside the city's colony, according to Deadline.

"Colony" is co -written by Cuse and Ryan Condal ("Hercules"). The pilot will be directed by Juan José Campanel ("House M.D.").

Callies' "The Walking Dead" character was killed off during the third season of the show, when her character died after Maggie (Lauren Cohan) gave her an emergency Cesarean Section. Carl (Chandler Riggs), Lori's teenage son Carl then dramatically shot her in the head, saving her from coming back as a walker.

Callies' Lori received a lot of negative reactions from fans during the second season of the hit AMC post-apocalyptic drama. Some described the character as an overprotective mom to Carl and a terrible wife to Rick. In fact, there was a significant segment of the show's viewership that called for her demise.

But when asked in an August interview with IGN what it was like for her to experience that kind of backlash as an actress, Callies answered: "Actually, I think it's wonderful. I think it's really honest. I come from theater...there's something about having a relationship with your audience that feels very honest as an actor."

"I don't need people to like me. I want people to engage with the stories I'm telling and feel passionate about them," she added. "So if they're feeling passionate about them one way or another, I feel like I'm doing my job."

Before her stint on "The Walking Dead," Callies co-starred on Fox's "Prison Break." The La Grange, Illinois-born actress recently appeared in the disaster film "Into The Storm" and finished filming for the upcoming horror film "The Other Side Of The Door." She is currently shooting the thriller film "Pay The Ghost" opposite Nicolas Cage.